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[4], from a large survey we conducted on over 1100 PA patients shows that 40% of PA patients wait two years or longer for diagnosis, further complicating patient outcomes and satisfaction (Thain et al., 2024, DOI: 10.1101/2024.08.30.24312837)

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Both endogenous GIP (52) and GLP-1 (53) have very short half-lives, measured in minutes, resulting in only a small portion of these active hormones reaching the systemic circulation

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If small-molecule chemistry can produce an oral GLP-1 agonist (orforglipron), can it also produce oral molecules that activate multiple metabolic receptors simultaneously

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